Armolipid PLUS should be taken once a day and does not require a prescription. It is recommended to be taken in combination with a healthy lifestyle and diet. The majority of cardiovascular disease is caused by risk factors that can be controlled, treated or modified. These risk factors include: high blood pressure, high cholesterol levels, overweight/obesity, smoking, lack of physical activity and diabetes. The European guidelines (European Society for Cardiology, in collaboration with the European Atherosclerosis Society) list a number of nutraceuticals, but many of them, unlike Armolipid PLUS, have not been studied in randomized, controlled clinical trials (RCTs). Armolipid PLUS is a patented formulation of three naturally occurring substances with complementary lipid-lowering properties – red yeast rice, policosanol and berberine – combined with folic acid, astaxanthin, and coenzyme Q10. Armolipid PLUS reduces cholesterol by the action of the following constituents: Red Yeast Rice – includes monacolins which are known to reduce plasma cholesterol. Berberine – a natural plant extract from Berberis aristata bark, which reduces cholesterol by increasing LDL-C receptors on the liver cell surface. Policosanol – reduces intracellular cholesterol by increasing cholesterol uptake by the liver from circulating lipoproteins.